Xing Fu

Title Associate Professor
Department School of Animal Sciences
E-mail XFu1@agcenter.lsu.edu
Address 1 229G AFSL Building
Baton Rouge, LA 70803
Phone 225-578-2121
Fax 225-578-4890

2023-present, Ralph and Lela Boulware Associate Professor, School of Animal Sciences, Louisiana State University

2022-present, Adjunct Faculty, Department of Biological and Agricultural Engineering, Louisiana State University

•2017-2023, Assistant Professor, School of Animal Sciences, Louisiana State University

•2016-2017, Postdoctoral Fellow, Cincinnati Children’s Hospital

•2011-2015, Ph.D. student, Animal Science, Washington State University

•2008-2010, M.S. student, Biology, Arkansas State University

•2003-2007, B.S. student, Biotechnology, Henan Normal University

My laboratory is interested in the biology of fibrogenic, adipogenic, and myogenic stem and progenitor cells, using various genomic tools, including bulk and single-cell RNAseq, ATACseq, and Cut&Tag.

The two major focuses in my lab now include:

1. Role of Cardiac fibroblasts in cardiac fibrosis.

2. Depot-specific regulation of adipogenesis

  • Liu Q, Li C, Deng B, Gao P, Wang L, Li Y, Shiri M, Alkaifi F, Zhao J, Stephens JM, Simintiras CA, Francis J, Sun J, Fu X. Progenitor cell isolation from mouse epididymal adipose tissue and sequencing library construction. Star Protocols. In press
  • Ford H, Liu Q, Fu X, Strieder-Barboza C. White adipose tissue heterogeneity in the single-cell era: from mice and humans to cattle. Biology. 2023;12(10):1289.
  • Wang L, Gao P, Li C, Liu Q, Yao Z, Li Y, Zhang X, Sun J, Simintiras C, Welborn M, McMillin K, Oprescu S, Kuang S, Fu X. A single-cell atlas of bovine skeletal muscle reveals mechanisms regulating intramuscular adipogenesis and fibrogenesis. J Cachexia Sarcopenia Muscle. 2023. Epub 2023/07/13. doi: 10.1002/jcsm.13292. PubMed PMID: 37439037.
  • Liu Q, Li C, Deng B, Gao P, Wang L, Li Y, Shiri M, Alkaifi F, Zhao J, Stephens JM, Simintiras CA, Francis J, Sun J, Fu X. Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development. Cell Rep. 2023;42(3):112166. Epub 2023/03/02. doi: 10.1016/j.celrep.2023.112166. PubMed PMID: 36857185.
  • Li Y, Li C, Liu Q, Wang L, Bao AX, Jung JP, Dodlapati S, Sun J, Gao P, Zhang X, Francis J, Molkentin JD, Fu X. Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction. J Mol Cell Cardiol. 2022;171:117-32. Epub 2022/08/26. doi: 10.1016/j.yjmcc.2022.08.003. PubMed PMID: 36007455.
  • Li C, Sun J, Liu Q, Dodlapati S, Ming H, Wang L, Li Y, Li R, Jiang Z, Francis J, Fu X. The landscape of accessible chromatin in quiescent cardiac fibroblasts and cardiac fibroblasts activated after myocardial infarction. Epigenetics. 2021:1-20. Epub 2021/09/24. doi: 10.1080/15592294.2021.1982158. PubMed PMID: 34551670.
  • Mehta N, Shaik S, Prasad A, Chaichi A, Sahu SP, Liu Q, Hasan SMA, Sheikh E, Donnarumma F, Murray KK, Fu X, Devireddy R, Gartia MR. Multimodal Label-Free Monitoring of Adipogenic Stem Cell Differentiation Using Endogenous Optical Biomarkers. Adv Funct Mater. 2021;31(43). Epub 2021/12/21. doi: 10.1002/adfm.202103955. PubMed PMID: 34924914; PMCID: PMC8680429.
  • Sahu SP, Liu Q, Prasad A, Hasan SMA, Liu Q, Rodriguez MXB, Mukhopadhyay O, Burk D, Francis J, Mukhopadhyay S, Fu X, Gartia MR. Characterization of fibrillar collagen isoforms in infarcted mouse hearts using second harmonic generation imaging. Biomed Opt Express. 2021;12(1):604-18. Epub 2021/02/02. doi: 10.1364/boe.410347. PubMed PMID: 33520391; PMCID: PMC7818962.
  • Fu X, Liu Q, Li C, Li Y, Wang L. Cardiac Fibrosis and Cardiac Fibroblast Lineage-Tracing: Recent Advances. Front Physiol. 2020;11:416. Epub 2020/05/22. doi: 10.3389/fphys.2020.00416. PubMed PMID: 32435205; PMCID: PMC7218116.
  • Dixon WR, Watts EG, King JA, Fu X, Wicker L. Shelf-Stable Sustainable Shrimp Thermally Processed With Reciprocal Agitation. Frontiers in Sustainable Food Systems. 2020:168.
  • Hu X, Xing Y, Fu X, Yang Q, Ren L, Wang Y, Li Q, Li J, Zhang L. NCAPG Dynamically Coordinates the Myogenesis of Fetal Bovine Tissue by Adjusting Chromatin Accessibility. Int J Mol Sci. 2020;21(4). Epub 2020/02/20. doi: 10.3390/ijms21041248. PubMed PMID: 32070024; PMCID: PMC7072915.
  • Li X, Fu X, Yang G, Du M. Review: Enhancing intramuscular fat development via targeting fibro-adipogenic progenitor cells in meat animals. Animal. 2020;14(2):312-21. Epub 2019/10/05. doi: 10.1017/s175173111900209x. PubMed PMID: 31581971.
  • Hu X, Xing Y, Ren L, Wang Y, Li Q, Fu X, Yang Q, Xu L, Willems L, Li J, Zhang L. Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B. Animals (Basel). 2019;9(11). Epub 2019/10/28. doi: 10.3390/ani9110859. PubMed PMID: 31652908; PMCID: PMC6912306.
  • Fu X, Li C, Liu Q, McMillin KW. GROWTH AND DEVELOPMENT SYMPOSIUM: STEM AND PROGENITOR CELLS IN ANIMAL GROWTH: The regulation of beef quality by resident progenitor cells1. J Anim Sci. 2019;97(6):2658-73. Epub 2019/04/16. doi: 10.1093/jas/skz111. PubMed PMID: 30982893; PMCID: PMC6541817.
  • Boyer JG, Prasad V, Song T, Lee D, Fu X, Grimes KM, Sargent MA, Sadayappan S, Molkentin JD. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI Insight. 2019;5(10). Epub 2019/04/10. doi: 10.1172/jci.insight.127356. PubMed PMID: 30964448; PMCID: PMC6542606.
  • Wang B, Nie W, Fu X, de Avila JM, Ma Y, Zhu MJ, Maquivar M, Parish SM, Busboom JR, Nelson ML, Du M. Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers. J Anim Sci Biotechnol. 2018;9:82. Epub 2018/11/22. doi: 10.1186/s40104-018-0296-3. PubMed PMID: 30459947; PMCID: PMC6236944.
  • Maliken BD, Kanisicak O, Karch J, Khalil H, Fu X, Boyer JG, Prasad V, Zheng Y, Molkentin JD. Gata4-Dependent Differentiation of c-Kit(+)-Derived Endothelial Cells Underlies Artefactual Cardiomyocyte Regeneration in the Heart. Circulation. 2018;138(10):1012-24. Epub 2018/04/19. doi: 10.1161/circulationaha.118.033703. PubMed PMID: 29666070; PMCID: PMC6125755.
  • Fu X, Yang Q, Wang B, Zhao J, Zhu M, Parish SM, Du M. Reduced satellite cell density and myogenesis in Wagyu compared with Angus cattle as a possible explanation of its high marbling. Animal. 2018;12(5):990-7. Epub 2017/10/11. doi: 10.1017/s1751731117002403. PubMed PMID: 28988554.
  • Fu X, Khalil H, Kanisicak O, Boyer JG, Vagnozzi RJ, Maliken BD, Sargent MA, Prasad V, Valiente-Alandi I, Blaxall BC, Molkentin JD. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. J Clin Invest. 2018;128(5):2127-43. Epub 2018/04/18. doi: 10.1172/jci98215. PubMed PMID: 29664017; PMCID: PMC5957472.
  • Zhang S, Zhang Y, Zhou X, Fu X, Michal JJ, Ji G, Du M, Davis JF, Jiang Z. Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice. Sci Rep. 2018;8(1):6462. Epub 2018/04/25. doi: 10.1038/s41598-018-24683-7. PubMed PMID: 29691479; PMCID: PMC5915415.
  • Sun X, Fu X, Du M, Zhu MJ. Ex vivo gut culture for studying differentiation and migration of small intestinal epithelial cells. Open Biol. 2018;8(4). Epub 2018/04/13. doi: 10.1098/rsob.170256. PubMed PMID: 29643147; PMCID: PMC5936714.
  • Khalil H, Kanisicak O, Prasad V, Correll RN, Fu X, Schips T, Vagnozzi RJ, Liu R, Huynh T, Lee SJ, Karch J, Molkentin JD. Fibroblast-specific TGF-β-Smad2/3 signaling underlies cardiac fibrosis. J Clin Invest. 2017;127(10):3770-83. Epub 2017/09/12. doi: 10.1172/jci94753. PubMed PMID: 28891814; PMCID: PMC5617658 exists.
  • Wang B, Fu X, Zhu MJ, Du M. Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation. J Mol Cell Biol. 2017;9(4):338-49. Epub 2017/10/11. doi: 10.1093/jmcb/mjx026. PubMed PMID: 28992291; PMCID: PMC6080365.
  • Wang B, Fu X, Liang X, Wang Z, Yang Q, Zou T, Nie W, Zhao J, Gao P, Zhu MJ, de Avila JM, Maricelli J, Rodgers BD, Du M. Maternal Retinoids Increase PDGFRα(+) Progenitor Population and Beige Adipogenesis in Progeny by Stimulating Vascular Development. EBioMedicine. 2017;18:288-99. Epub 2017/04/15. doi: 10.1016/j.ebiom.2017.03.041. PubMed PMID: 28408241; PMCID: PMC5405191.
  • Wang S, Liang X, Yang Q, Fu X, Zhu M, Rodgers BD, Jiang Q, Dodson MV, Du M. Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) α1 in mice fed high-fat diet. Mol Nutr Food Res. 2017;61(4). Epub 2016/11/23. doi: 10.1002/mnfr.201600746. PubMed PMID: 27873458; PMCID: PMC5538732.
  • Yang Q, Liang X, Sun X, Zhang L, Fu X, Rogers CJ, Berim A, Zhang S, Wang S, Wang B, Foretz M, Viollet B, Gang DR, Rodgers BD, Zhu MJ, Du M. AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis. Cell Metab. 2016;24(4):542-54. Epub 2016/09/20. doi: 10.1016/j.cmet.2016.08.010. PubMed PMID: 27641099; PMCID: PMC5061633.
  • Liang X, Yang Q, Fu X, Rogers CJ, Wang B, Pan H, Zhu MJ, Nathanielsz PW, Du M. Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. J Physiol. 2016;594(15):4453-66. Epub 2016/04/10. doi: 10.1113/jp272123. PubMed PMID: 27060371; PMCID: PMC4967739.
  • Miao ZG, Zhang LP, Fu X, Yang QY, Zhu MJ, Dodson MV, Du M. Invited review: mesenchymal progenitor cells in intramuscular connective tissue development. Animal. 2016;10(1):75-81. Epub 2015/09/10. doi: 10.1017/s1751731115001834. PubMed PMID: 26350682; PMCID: PMC5922451.
  • Fu X, Zhu M, Zhang S, Foretz M, Viollet B, Du M. Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK. Diabetes. 2016;65(1):188-200. Epub 2015/09/19. doi: 10.2337/db15-0647. PubMed PMID: 26384382; PMCID: PMC4686944.
  • Du M, Wang B, Fu X, Yang Q, Zhu MJ. Fetal programming in meat production. Meat Sci. 2015;109:40-7. Epub 2015/05/09. doi: 10.1016/j.meatsci.2015.04.010. PubMed PMID: 25953215.
  • Fu X, Zhu MJ, Dodson MV, Du M. AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. J Biol Chem. 2015;290(44):26445-56. Epub 2015/09/16. doi: 10.1074/jbc.M115.665232. PubMed PMID: 26370082; PMCID: PMC4646303.
  • Wang S, Liang X, Yang Q, Fu X, Rogers CJ, Zhu M, Rodgers BD, Jiang Q, Dodson MV, Du M. Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1. Int J Obes (Lond). 2015;39(6):967-76. Epub 2015/03/13. doi: 10.1038/ijo.2015.23. PubMed PMID: 25761413; PMCID: PMC4575949.
  • Wei S, Fu X, Liang X, Zhu MJ, Jiang Z, Parish SM, Dodson MV, Zan L, Du M. Enhanced mitogenesis in stromal vascular cells derived from subcutaneous adipose tissue of Wagyu compared with those of Angus cattle. J Anim Sci. 2015;93(3):1015-24. Epub 2015/05/29. doi: 10.2527/jas.2014-7923. PubMed PMID: 26020879.
  • Fu X, Zhao JX, Zhu MJ, Foretz M, Viollet B, Dodson MV, Du M. AMP-activated protein kinase α1 but not α2 catalytic subunit potentiates myogenin expression and myogenesis. Mol Cell Biol. 2013;33(22):4517-25. Epub 2013/09/18. doi: 10.1128/mcb.01078-13. PubMed PMID: 24043309; PMCID: PMC3838187.
  • Fu X, Zhao JX, Liang J, Zhu MJ, Foretz M, Viollet B, Du M. AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5. Am J Physiol Cell Physiol. 2013;305(8):C887-95. Epub 2013/08/09. doi: 10.1152/ajpcell.00124.2013. PubMed PMID: 23926128; PMCID: PMC3798682.
  • Duarte MS, Paulino PV, Das AK, Wei S, Serão NV, Fu X, Harris SM, Dodson MV, Du M. Enhancement of adipogenesis and fibrogenesis in skeletal muscle of Wagyu compared with Angus cattle. J Anim Sci. 2013;91(6):2938-46. Epub 2013/03/20. doi: 10.2527/jas.2012-5892. PubMed PMID: 23508025.
  • Das AK, Yang QY, Fu X, Liang JF, Duarte MS, Zhu MJ, Trobridge GD, Du M. AMP-activated protein kinase stimulates myostatin expression in C2C12 cells. Biochem Biophys Res Commun. 2012;427(1):36-40. Epub 2012/09/22. doi: 10.1016/j.bbrc.2012.08.138. PubMed PMID: 22995402; PMCID: PMC3486733.

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