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Alterations in gut microbiome composition and metabolism are associated with neurodegenerative pathologies, barrier dysfunction, and cognitive decline. We apply a standardized bioinformatics workflows to evaluate shared microbial and predicted metabolic pathway signatures associated with Alzheimer’s Disease, providing potential for future precise and effective microbiome-informed therapeutic strategies.
Early life is a critical window for the maturation of the gut microbiome, gastrointestinal barrier, immune system, and brain development. The microbiota–gut–brain axis plays an essential role during this period, with diet as a major modulator. We discovered that the metabolism of dietary components by infant-associated microbes such as Bifidobacterium infantis is critical for developing health-impacting nutritive strategies. We explore how this critical interaction affects development and behavior.
Both bifidobacterial and lactobacilli species are known GABA, SCFA, and acetylcholine producers, however, these traits are highly strain- and substrate-specific. We find that some species are sensitive to substrates available to produce acetate, lactate, and GABA. We explore how specifically dietary oils affect their metabolism in a way that influence microbiota-gut-brain axis.
