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LSU AgCenter scientists have developed an innovative technology to improve the solubility of pharmaceutical and bioactive substances that struggle to dissolve.
LSU AgCenter faculty have utilized natural plant derivatives to increase the solubility and permeability of paclitaxel to allow for oral administration. The derivatives replace harmful chemical and synthetic solvents normally required for paclitaxel to be absorbed by the body. This development could change not only the methodology of administration of paclitaxel from injection to oral but also make paclitaxel available as a preventative measure against the recurrence of cancer.
This invention is a method of creating tunable polymer matrices that entraps bioactive components. The particles can entrap compounds such as lutein that can reduce the risk of age related macular degeneration. The bioactive compounds can also function as antioxidants. The matrices increase the stability of the entrapped components allowing a greater amount of them to reach a desired location and have a beneficial effect.
AgCenter scientists have developed a new encapsulation formulation to increase the solubility of statin and icariin compounds. The increase in solubility was tens of thousands fold for both compounds according to lab experiments. This can greatly increase the bioavailability, or absorption into the body, of statin- and icariin-related drugs. Both concepts have been formulated into powders with relatively high drug loads. All ingredients used in the process are natural.
A new natural plant extract has been discovered that inhibits cell signaling pathways to prevent certain cells from communicating and growing. By strongly inhibiting multiple cell signaling pathways, such as mTOR and P13K/Akt, this new material can eliminate very late-stage prostate cancers that have previously been difficult to treat. It also can block certain proteins and enzymes linked to diabetes, obesity and tissue inflammation.
This invention is a novel combination of natural extracts that has the ability to strongly inhibit the development of blood vessels that feed cancer and other diseases related to blood vessel growth, such as psoriasis. The synergistic interaction of these materials increases efficacy, and the body can readily absorb the extracts through the skin. This material also has shown promise in vitro to overcome cells’ natural drug resistance and defenses.
This new group of compounds uses natural extracts to increase the solubility of drugs. Unlike other solubility-enhancing compounds, these will work on molecules of any size and will not slow down the speed at which drugs enter circulation and move throughout the body. This technology has been licensed. Please contact the AgCenter Office of Intellectual Property for information on partnering with our licensee.
AgCenter scientists have invented a vaccine and diagnostic for Bovine Coronavirus (BCoV). Studies with the vaccine have shown that it helps cattle’s immune system produce more BCoV antibodies to fight the disease and protects the herd from catching virus from other infected cattle. Elements of the vaccine can be purified to form an advanced diagnostic that can detect the presence of BCoV to help isolate and prevent future outbreaks.
AgCenter scientists have created a new molecule to stop atherosclerosis. The molecule prevents plaque from building on and sticking to the artery walls, reducing the chances of blood clots that can lead to heart attacks and strokes. It functions as an antioxidant designed to stick to plaque better and prevent more from forming.
