Method To Diagnose Metabolic Pyrethroid Insecticide Resistance

William Baumgartner, Ottea, James A.  |  8/18/2007 12:31:01 AM

Ottea, James A.; Shan, Guomin
Date Posted: 3/5/2002
Patent Status: issued
Patent Number: 6,150,404

Abstract:
The phenoxybenzyl moiety of conventional pyrethroids is a major site of oxidative metabolism in resistant tobacco budworms, Heliothis virescens (F.). This group was replaced with several P450 monooxygenase-inhibiting or oxidatively blocked groups. Several isomers were tested as insecticides or synergists for insecticides against tobacco budworms that were insecticide-susceptible or that expressed metabolic resistance to cypermethrin. Several compounds with insecticidal and synergistic activities were found. Activity was dependent on both geometric and stereochemical configurations. These compounds may be used in diagnosing the mechanism of resistance in field strains with acquired resistance to pyrethroids. Knowledge of the mechanism underlying acquired insecticide resistance helps farmers to control emerging resistant strains.
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