TOPICS
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Name: Frank Bastian
Title: Professor
Specialization: Neuropathology
E-mail: 
Department: Veterinary Science Department
Organization: LSU AgCenter
Address 1: Veterinary Science Building
Address 2: Baton Rouge, LA 70803 - 6002
Phone Number: (225) 578-4324
Fax Number: (225) 578-4890
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Education/Training
- BA, Biology, University of Saskatchewan, 1960
- MD, University of Saskatchewan, 1964
- Residency, Neuropathology, Duke University, 1968-72
- Fellowship, Virology, National Institutes of Health, 1972
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Areas of Specialization/Research
Dr. Bastian’s research centers around a lifetime work searching for the causal agent of the transmissible spongiform encephalopathies (TSE). He has shown that a wall-less bacterium, spiroplasma, is consistently associated with the TSEs. Recently at LSU Agricultural Center, he and collaborators in the Dept. of Veterinary Science have developed a Ruminant Model of TSE that will be used to study pathogenic mechanisms involved in the spiroplasmosis models. In collaboration with Dr. Thune, a genomic study will be conducted on the putative organism, which should dramatically help understand the role of spiroplasma in TSE.
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Professional Experience
1972-1979 Assistant Professor, Baylor College of Medicine, Houston, TX
1979-1982 Associate Professor of Pathology, University of Maryland, Baltimore, MD
1982 - 1992 Associate Professor of Pathology, University of South Alabama College of Medicine, Mobile, AL 36619
1992 - 2001 Professor of Pathology, University of South Alabama College of Medicine, Mobile, AL 36619
2002 - date Professor of Pathology at Tulane University School of Medicine at New Orleans, Louisiana 70112.
2005 – date Professor, Dept of Veterinary Science, LSU Agricultural Center, Baton Rouge, Louisiana 70803.
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Awards/Grants
1984 Visiting Professor, Cambridge University, England
2002 Reviewer, Army Prion Program
2002 - 2003 Reviewer (Ad hoc chairman) Army Prion Program
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Publications/Presentations/Patents
Bastian FO, Rabson AS, Yee CL, Tralka TS: Herpes virus hominis: Isolation from human trigeminal ganglion Science l972;178:306-307.
Bastian FO, Rabson AS, Yee CL, Tralka TS. Herpes virus varicellae: isolation from human dorsal root ganglia. Arch Pathol 1974;97:331.
Bastian FO. Spiroplasma-like inclusions in Creutzfeldt-Jakob disease. Arch Pathol Lab Med 1979;103:665-669.
Bastian FO, Hart MN, Cancila PA. Additional evidence of spiroplasma in Creutzfeldt-Jakob disease. Lancet 1980; 1:660.
FO, Rabson AS, Yee CL, Tralka TS. Herpes virus hominis: isolation from human trigeminal ganglion. Science 1972
Bastian FO, Purnell DM, Tully JG. Neuropathology of spiroplasma infection in the rat brain. Am J Pathol 1984;114:496-514.
Tully JG, Bastian FO, Rose DL. Localization and persistence of spiroplasma in an experimental brain infection in suckling rats. Ann Microbiol 1984;135:111-117.
Bastian FO, Jennings RA, Gardner WA. Antiserum to scrapie-associated fibril protein cross-reacts with Spiroplasma mirum fibril protein. J Clin Microbiol 1987;25:2430-2431.
Bastian FO, Jennings RA, Huff C. Neurotropic response of Spiroplasma mirum following peripheral inoculation in the rat. Ann Microbiol 1987;138:651.
Bastian FO, Baliga BS, Pollock HM. Evaluation of a modified 3Hthymidine uptake method for studying growth of spiroplasmas under varying conditions. J Clin Microbiol 1988;26:2124-2126.
Bastian FO, Jennings RA, Hoff CJ. Effect of trimethoprim/sulphasoxazole and hyperbaric oxygen on experimental Spiroplasma mirum encephalitis. Ann Microbiol 1989;140:151-158.
Bastian FO. Review of theories on the nature of the transmissible agent. In: Bastian FO, ed. Creutzfeldt-Jakob disease and other transmissible spongiform encephalopathies. St. Louis: Mosby/Year Book, 1991.
Bastian FO. Bovine spongiform encephalopathy: relationship to human disease and nature of the agent. ASM News 1993;59:235-240.
Brown P, Cervenakova, Goldfarb LG, Bishop K, Bastian FO, Kirkpatrick J, Piccardo P, Ghetti B, Gajdusek DC. Creutzfeldt-Jakob disease in a husband and wife. Neurology 1998;50: 684-688.
Bastian FO, Foster JW. Spiroplasma sp. 16S rDNA om Creutzfeldt-Jakob disease and scrapie as shown by PCR and DNA sequence analysis. J Neuropathol Exp Neurol 2001;60: 613-620.
Bastian FO, Dash S, Garry RF. Linking chronic wasting disease to scrapie by comparison of Spiroplasma mirum ribosomal DNA sequences Exp Molecular Pathol 2004;77: 49– 56
Bastian FO, McDermott ME, Perry AS, Carver LA, Dash S, Garry RF. Safe method for isolation of prion protein and diagnosis of Creutzfeldt-Jakob disease. J Virol Meth 2005;130: 133-139.
B
astian FO. Spiroplasma as a candidate agent for the transmissible spongiform encephalopathies. J Neuropathol Exp Neurol 2005;64:833-838.
Bastian, FO, Sanders, DE, Forbes, WA, Hagius, SD, Walker, JV, Henk, WG, Enright, FM, Elzer, PH. Spiroplasma spp. from transmissible spongiform encephalopathy brains or ticks induce spongiform encephalopathy in ruminants. J Med Microbiol 2007; 56:1235-1242.
Book
Bastian, FO. Creutzfeldt-Jakob and Other Transmissible Spongiform Encephalopathies. New York: Mosby/Year book, 1991.
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