Hansel, William; Lim, Jeong-Mook
Date Posted: 3/5/2002
Patent Status: issued
Patent Number: 6,255,109
Abstract:
Nitric oxide adversely affects survival and development of cells such as oocytes and embryos in vitro, particularly in a co-culture system. The addition of a nitric oxide inhibitor such as hemoglobin to such systems eliminates this toxic effect, and promotes mammalian oocytes, embryos, or other cells in vitro.